Vol 6, No 1-2 (2023)

In modern pathological anatomy, the morphological diagnosis of malignant tumors aims not only to histogenetically verify the neoplasm, but also to maximally to form an intravital pathological report with indication of necessary categories for staging the process, as well as to identify structural markers of predictive value. The clinical guidelines of the Russian Ministry of Health, recommendations of public professional foreign and domestic societies prescribed the main parameters of malignant neoplasms, which should be specified in the intravital pathological report. However, dynamically developing scientific directions in oncology, pathological anatomy, and molecular genetics pose new challenges in the search of prognostic parameters of malignant neoplasms. Uveal melanoma is the most common intraocular tumor associated with distant metastases regardless of the type of treatment performed. For many decades, the structure and content of the morphologic report of uveal melanoma has remained unchanged. This article presents a review of standards and new directions in the intravital pathological macro- and microscopic diagnostics of uveal melanoma.

The understanding of kidney tumors has undergone great changes over the past 20 years. The article provides an analysis of the new classification of kidney tumors and its reform. The 5^th edition of the World Health Organization classification of tumors of the urinary system and male genital organs reflects the development of the concept laid down in previous editions. The conceptual organization of the classification of renal tumors has been transformed and improved, and new types have been included.

Mixed neuroendocrine-nonneuroendocrine neoplasms of the digestive tract are a rare heterogeneous group of tumors. For many years, the diagnostic criteria, classification and clinical behavior of these tumors have been the subject of constant discussion, which has led to confusion among both pathologists and clinicians. The purpose of this review is to describe the epidemiological, clinical and pathological characteristics and prognosis of mixed neuroendocrine-nonneuroendocrine neoplasms of the gastrointestinal tract, as well as to focus on the latest published data, including genetic data, in order to give some insight into the biology and pathogenesis of this rare disease. As an illustration of the mixed neuroendocrine-nonneuroendocrine neoplasms, this paper presents several of its own clinical cases.