OncopathologyOncopathologyОнкопатология2618-70193034-3534Publishing House ABV Press70842310.17650/2618-7019-2019-2-1-2-10-21MSHFPFReviews and lecturesОбзоры и лекцииResearch ArticlePharmacogenetic testing for individualization of hormonal therapy with tamoxifenФАРМАКОГЕНЕТИЧЕСКОЕ ТЕСТИРОВАНИЕ ДЛЯ ИНДИВИДУАЛИЗАЦИИ ГОРМОНОТЕРАПИИ ТАМОКСИФЕНОМLyubchenkoL. N.ЛюбченкоЛюдмила Николаевнаclingen@mail.ruFilippovaM. G.ФилипповаМ. Г.MekhtievaN. I.МехтиеваН. И.N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России0703201921-2102109062026Copyright ©; 2026, ABV-PressCopyright ©; 2026, АБВ-пресс2026ABV-PressАБВ-прессhttps://oncopathology.abvpress.ru/2618-7019/about/editorialPolicieshttps://oncopathology.abvpress.ru/2618-7019/article/view/708423

Tamoxifen is a drug of choice for endocrine therapy of hormone receptor-positive breast cancer in women of the reproductive period. The metabolic activity of tamoxifen is determined by the activity of the enzyme CYP2D6, encoded by the gene of the same name: under the action of the enzyme, tamoxifen passes into the metabolically active form, endoxyphene. Pharmacogenetic testing of the CYP2D6 gene in patients with hormone-positive breast cancer can help predict the effectiveness of therapy and assess the risk of side effects with the aim of improving long-term treatment outcomes.

Тамоксифен является препаратом выбора при эндокринотерапии гормоноположительного рака молочной железы у женщин. Метаболическая активность тамоксифена в организме определяется активностью фермента CYP2D6, кодируемого одноименным геном: под действием фермента тамоксифен переходит в метаболически активную форму - эндоксифен. Фармакогенетическое тестирование гена CYP2D6у пациенток с гормоноположительным раком молочной железы поможет прогнозировать эффективность терапии и оценить риск развития побочных эффектов с целью улучшения отдаленных результатов лечения.

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