Management of laboratory safety and quality of research in neuromorphology

Introduction. In modern pathological anatomy, the dominant pre-mortem histopathological diagnosis requires health management professionals and specialists in the Pathological Anatomy Service to ensure proper laboratory organization, with particular attention paid to laboratory safety and research quality. Aim. To analyze laboratory safety and research quality issues at Pathology Department (PD) of National Center for Neurosurgery (NCN). Materials and methods. The structure of PD of NCN, standard operating procedures of PD, and safety reports for the buildings of NCN were examined. The main research methods include informational-analytical, functional, and expert analyses. Results. Issues of laboratory safety and research quality at PD of NCN are addressed on an ongoing basis at all stages of the research process (pre-analytical, analytical, and post-analytical phases), in accordance with the developed laboratory safety program, standard operating procedures, and quality indicators. Safety and quality control in laboratory diagnostics in pathology are integral parts of healthcare control. Conclusion. The laboratory operates in compliance with the legislation of the Republic of Kazakhstan, the developed laboratory safety program, standard operating procedures, and quality indicators. To ensure the quality of laboratory work, the entire process of preparing histological specimens has been automated and standardized. Quality indicators for histopathological diagnosis should be viewed as a tangible contribution of clinical pathology to the protection of public health. Both internal and external audits of histological specimens and reports should be carried out. Noncompliance with laboratory safety rules and research quality standards directly affects the quality of histopathological diagnosis, with serious consequences for patient health.

laboratory safety, research safety, pathology, pathological anatomy, immunohistochemistry, molecular genetic studies, quality control of laboratory research