Treatment-induced breast angiosarcomas

Cover Page

Cite item

Full Text

Abstract

Breast angiosarcoma is a rare aggressive cancer with dismal prognosis and high risk of recurrence. Breast angiosarcomas can be divided into two categories depending on their causes: primary and secondary. Secondary angiosarcomas are usually induced by previous treatment for breast cancer and are further divided into radiation-induced secondary angiosarcomas and skin angiosarcomas developed due to chronic lymphostasis after lymph node dissection following radical mastectomy in combination with radiotherapy and polychemotherapy (Stewart-Treves syndrome). In this article, we report rare cases of secondary radiation-induced angiosarcomas and Stewart-Treves syndrome.

About the authors

Nina Andreevna Gorban

Central Clinical Hospital with Polyclinic, Administration of the President of the Russian Federation

Email: perovanina@mail.ru

D. S. Kushch

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: abv@abvpress.ru
Russian Federation

M. V. Mnikhovich

A.P. Avtsyn Research Institute of Human Morphology

Email: abv@abvpress.ru
Russian Federation

I. I. Andrienko

Klin Regional Hospital

Email: abv@abvpress.ru
Russian Federation

A. G. Titov

Klin Regional Hospital

Email: abv@abvpress.ru
Russian Federation

N. A. Korsakova

Central Clinical Hospital with Polyclinic, Administration of the President of the Russian Federation

Email: abv@abvpress.ru
Russian Federation

I. A. Sukhorukova

Central Clinical Hospital with Polyclinic, Administration of the President of the Russian Federation

Email: abv@abvpress.ru
Russian Federation

N. Yu. Turovskaya

Central Clinical Hospital with Polyclinic, Administration of the President of the Russian Federation

Email: abv@abvpress.ru
Russian Federation

A. G. Kudaybergenova

N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: abv@abvpress.ru
Russian Federation

References

  1. May D.S., Stroup N.E. The incidence of sarcomas of the breast among women in the United States, 1973-1986. Plast Reconstr Surg 1991;87(1):193-4. doi: 10.1097/00006534-19910100000045.
  2. Huang J., Mackillop WJ. Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer 2001;92(1):172-80. doi: 10.1002/1097-0142(20010701)92: 1<172::aid-cncr1306>3.0.co;2-k.
  3. Tan P.H., Ellis I., Allison K. et al. The 2019 World Health Organization classification of tumours of the breast. Histopathology 2020;77(2):181-5. doi: 10.1111/his.14091.
  4. Fineberg S., Rosen P.P. Cutaneous angiosarcoma and atypical vascular lesions of the skin and breast after radiation therapy for breast carcinoma. Am J Clin Pathol 1994;102(6):757-63. doi: 10.1093/ajcp/102.6.757.
  5. Cohen-Hallaleh R.B., Smith H.G., Smith R.C. Radiation induced angiosarcoma of the breast: outcomes from a retrospective case series. Clin Sarcoma Res 2017; 7:15. doi: 10.1186/s13569-017-0081-7.
  6. Будик Ю.А., Любченко Л.Н., Анурова О.А. и др. Первичные генетически обусловленные ангиосаркомы молочных желез у близнецовой пары. Клинический случай. Саркомы костей, мягких тканей и опухоли кожи 2011;(3):66-74.
  7. Baker G.M., Schnitt S.J. Vascular lesions of the breast. Semin Diagnostic Pathol 2017;34(5):410-9. doi: 10.1053/j.semdp.2017.05.013.
  8. Machado I., Giner F., Lavernia J. et al. Angiosarcomas: histology, immunohisto-chemistry and molecular insights with implications for differential diagnosis. Histol Histopathol 2021;36(1):3-18. doi: 10.14670/HH-18-246.
  9. Ryabchikov D.A., Vorotnikov I.K., Chkhikvadze N.V. et al. Breast sarcomas. Literature review. Tumors of Female Reproductive System 2014;2:12-5. doi: 10.17650/1994-4098-20140-2-12-15.
  10. Oliveira A.M., Nascimento A.G. Grading in soft tissue tumors: principles and problems. Skeletal Radiol 2001;30(10):543-59. doi: 10.1007/s002560100408.
  11. WHO Classification of Tumors of Soft Tissue and Bone. Ed. by C. Fletcher et al. Lyon: IARC Press, 2020.
  12. Fraga-Guedes C., Gobbi H., Mastropasqua M.G. et al. Primary and secondary angiosarcomas of the breast: a single institution experience. Breast Cancer Res Treat 2012;132(3):1081-8.
  13. Antonescu C. Malignant vascular tumors - an update. Mod Pathol 2014;27(Suppl 1):S30-8.
  14. Корчагина А.А., Шеин С.А., Турина О.И., Чехонин В.П. Роль рецепторов VEGFR в неопластическом ангиогенезе и перспективы терапии опухолей мозга. Вестник Российской академии медицинских наук 2013;68(11):104-14. doi: 10.15690/vramn. v68i11.851.
  15. Abdou Y., Elkhanany A., Attwood K. et al. Primary and secondary breast angiosarcoma: single center report and a meta-analysis. Breast Cancer Res Treat 2019;178(3):523-33. doi: 10.1007/s10549-019-05432-4.
  16. Borman P., Yaman A., Gokoz O. Stewart- Treves syndrome: A rare but aggressive complication of breast cancer-related lymphedema. Eur J Breast Health 2021;17(4):378-82. doi: 10.4274/ejbh.galenos.2020.5741.
  17. Sharma A., Schwartz R.A. Stewart-Treves syndrome: Pathogenesis and management. J Am Acad Dermatol 2012;67(6):1342-8.
  18. Leite L.L., Rossato V. Stewart-Treves syndrome as a rare and fatal complication of post-traumatic lymphedema on the lower extremity. Dermatol Pract Concept 2021;11(2):e2021004. doi: 10.5826/dpc.1102a04.
  19. Shon W., Ida C.M., Boland-Froemming J.M. et al. Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature. J Cutan Pathol 2011;38(7):560-4. doi: 10.1111/j.1600-0560.2011.01703.x.
  20. Simas A., Matos C., Lopes da Silva R. et al. Epithelioid angiosarcoma in a patient with Klippel-Trenaunay-Weber syndrome: An unexpected response to therapy. Case Rep Oncol 2010;3(2):148-53. doi: 10.1159/000313990.
  21. Stanczyk M., Gewartowska M., Swierkowski M. et al. Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood andlymphatic capillaries. Chin Med J (Engl) 2013;126(2):231-7.
  22. Young R.J., Brown N.J., Reed M.W. et al. Angiosarcoma. Lancet Oncol 2010;11(10):983-91.
  23. Vojtisek R., Sukovska E., Kylarova M. et al. Stewart-Treves syndrome: Case report and literature review. Rep Pract Oncol Radiother 2020;25(6):934-8. doi: 10.1016/j.rpor.2020.09.006.
  24. McHaffie D.R., Kozak K.R., Warner T.F. et al. Stewart-Treves syndrome of the lower extremity. J Clin Oncol 2010;28(21):e351-2.
  25. Cui L., Zhang J., Zhang X. et al. Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature. Int J Clin Exp Pathol 2015;8(9):11108-15.
  26. Gottlieb R., Serang R., Chi D., Menco H. Stewart-Treves syndrome. Radiol Case Rep 2015;7(4):693.
  27. Grobmyer S.R., Daly J.M., Glotzbach R.E., Grobmyer A.J. Role of surgery in the management of postmastectomy extremity angiosarcoma (Stewart-Treves syndrome). J Surg Oncol 2000;73(3):182-8.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2026 ABV-Press

License URL: https://oncopathology.abvpress.ru/2618-7019/about/editorialPolicies
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-87351 от 27.04.2024.